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Annals of Pharmacotherapy, 30(10), 10751079
Metabolic Modulators: Multiple Phase I/II clinical trials have shown that the pyruvate dehydrogenase kinase (PDK) inhibitor dichloroacetate (DCA), used alone or in combination with chemoradiotherapy, demonstrates good safety and preliminary efficacy in some patients with advanced solid tumors [172, 173]
Diagn Res
A randomized, double-blind, placebo-controlled trial in 28 older women (ages, 65-70 years) found no effect of L-carnitine supplementation (1.5 g/day for 24 weeks) on serum pro-inflammatory cytokine concentrations, body mass and composition (lean [fat-free] mass and skeletal muscle mass), or measures of skeletal muscle strength (123)
muciniphila supplementation also improved mitochondrial biogenesis and energy metabolism via PPAR signaling
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