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Distribution studies indicate PT-141 crosses the blood-brain barrier effectively, consistent with its centrally-mediated mechanism of action
Huber, Monika Kreyenbuehl, Heike Gutmann, Jrgen Drewe, Christoph Henzen, Burkhard Goeke, Christoph Beglinger, Glucagon-Like Peptide 1 Induces Natriuresis in Healthy Subjects and in Insulin-Resistant Obese Men, The Journal of Clinical Endocrinology & Metabolism , Volume 89, Issue 6, 1 June 2004, Pages 30553061, Weiss, E
They also found that Schwann cell and melanocyte development share signaling molecules with both the glial and melanocyte cell fates linked to nerve contact and regulated in an opposing manner by various growth factors
& Bianchini, M
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