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Normal doses of NAC (around 500-600 milligrams daily) are generally safe, but side effects may include nausea, vomiting and headache.

When investigating elevated B12, additional tests such as active B12 (holotranscobalamin), methylmalonic acid, and homocysteine may help clarify true B12 status

B6 also plays an important role in immune functions and is also a bio-marker of inflammation with its down-regulation being associated with severe inflammation (16)

In animal models of DKD, drugs like canagliflozin, dapagliflozin, and empagliflozin increase FAO enzymes, improve how kidneys handle lipids and reduce injury (Lu et al., 2022

The supplement may not be suitable for individuals with certain medical conditions or those taking certain medications

Whether this translates to human risk is not established, but the medication is contraindicated in anyone with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2