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While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition

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Another commenter requested clarification on whether multiple outreach attempts and reminders would be permitted in order to improve survey response rates

Avoid strenuous physical activity immediately after your shot

Most patients notice higher energy and improved focus within 2472 hours of treatment