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Since it is suggested that p53, p16, p21 are directly related to the induction of senescence in chondrocytes ( IL-6 and -8 , which however were not detectable due to the low expression level

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Butler LM, Agus DB, Scher HI, Higgins B, Rose A, Cordon-Cardo C et al

Kruse, T., Hansen, J

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