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[76] found no evidence of increased risk of suicidal ideation and self-injury associated with GLP-1 RAs compared to SGLT-2 inhibitors in individuals with T2DM and obesity, based on data from the Valencia Health System Integrated Database (VID) (per-protocol analysis: HR, 1.04

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In addition to SCFAs and IS, p-CS, another gut-derived uremic toxin, has been implicated in CKD-related neuroinflammation (Meijers and Evenepoel, 2011)

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For some patients, micro-dosing may help reduce the risk of weight regain by minimizing sudden changes in appetite and hunger signals