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Voronin MV, Vakhitova YV, Seredenin SB

In general, by either excess or impairment, NO appears to cause or contribute to a variety of disturbances, in particular, hypertension, angina, impotence, circulatory shock, septic shock, stroke, inflammation, respiratory distress syndromes, pulmonary hypertension, adhesion and aggregation of platelets and leukocytes, diabetes, hypotension, and Parkinson's disease

10.1016/j.bbagen.2013.02.017 9 BozinovskiS.SeowH

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In addition, given that immune checkpoint inhibitors are now widely used to treat cancer, the role of glutamine blockade within the tumor microenvironment (TME) has gained much attention 7

DRG are enclosed within the dural sac, 15 albeit at a uniquely permeable site of the blood-brain barrier