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So, what I envision is going to happen is that people are going to be seen earlier and treated earlier, said Aronne

Reduced serum free carnitine as well as reduced levels of 3-keto-VPA, the main metabolite of -oxidation of VPA, was first reported in 1982 by Bohles and coworkers [53] in a 3-year-old girl who developed acute liver disease with typical features of Reye's syndrome after treatment with VPA for 6 months

Treatment of Philadelphia chromosome-positive acute lymphocytic leukemia with hyper-CVAD and imatinib mesylate

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Preclinical data from a DHEA-induced PCOS rat model demonstrate that DNase I treatment reduces hepatic NET deposition and improves glucose metabolism [5]