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In fact, she says, when scientists started considering mRNA as a vaccine strategy some 30 years ago, they rejected the idea, in part because of concerns that it would overstimulate inflammatory pathways

Brain Res Brain Res Rev 26:230235 Nawashiro H, Martin D, Hallenbeck JM (1997a) Inhibition of tumor necrosis factor and amelioration of brain infarction in mice

however, in certain high-risk groups it occurs about 1 in 10,000 per year

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doi:10.1016/j.jnutbio.2010.10.005 Kansanen E, Kuosmanen SM, Leinonen H, Levonen AL (2013) The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer

Clinical Assessment Additional testing may be recommended where appropriate to ensure accurate diagnosis and treatment planning