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Osmotic pump drug delivery systems-a comprehensive review

doi: 10.1021/ja400119t

Imagine, an adult human having to swim against a strong current for weeks on end without interruption, overcoming towering waves and sometimes dozens of meters high waterfalls

Further, secretion of gastric juices naturally increases after food consumption, and meal viscosity has been found to stimulate the secretion even more [12]

The threshold for concern is clear, and it's higher than most people assume