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Low-dose naltrexone (LDN) has emerged as one of the most promising agents in this area, working through glial cell modulation to reduce neuroinflammation and through toll-like receptor pathways to quiet abnormal immune activation

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In these trials, GLP1-RAs have consistently demonstrated benefits for both primary cardiovascular and secondary kidney outcomes

To better understand appetite changes and satiety, see our how GLP-1 actually works for weight loss

Similarly, the study could not find any association between changes in circulating GLP-1 and changes in IBS symptom severity, highlighting the need for identifying underlying mechanisms driving these changes

Suspected adverse reactions should be reported through the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk or via the Yellow Card app), contributing to ongoing medication safety surveillance