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Yes, nausea is a common and expected side effect of semaglutide and clinical trials, and the product labels for both Wegovy and Ozempic list nausea, vomiting, and other gastrointestinal symptoms as the most frequently experienced side effects

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The medication slows gastric emptying, which can affect the absorption of other oral medications

Furthermore, imbalance between L-arginine and ADMA, an endogenous inhibitor of eNOS, leading to reduced L-arginine/ADMA ratio, contributes to eNOS uncoupling (Closs et al., 2012

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