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Patients often notice sleep onset, sleep depth, or sleep continuity changes within two to four weeks of completing the loading cycle

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It carries a boxed warning regarding the risk of thyroid C-cell tumors observed in rodents, and it should not be used in patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

For people with T2D and atherosclerotic cardiovascular disease (ASCVD) or high CV risk, clinical guidelines developed by the American Diabetes Association and the European Association for the Study of Diabetes specifically recommend the use of glucagon-like peptide 1 receptor agonists (GLP-1 RAs) or sodiumglucose cotransporter 2 inhibitors (SGLT2is) [9, 10], irrespective of baseline blood glucose levels or metformin use