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CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency

However, despite this significant elevation, GDF15 showed no statistically significant correlation with clinical severity measured by FIQR scores

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NO and mitochondria Role of NO in mitochondrial biogenesis Although the underlying mechanisms are not fully understood, several studies indicate an interaction between NO and a mitochondrial biogenesis regulator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1) (Lira et al., 2010