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Later, this question was further explored by Mutvei et al

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FDA-approved medications undergo extensive safety testing and clinical trials before they are available to the public

This review discusses the pathogenesis of epilepsy associated with ten vitamins from five perspectives, namely, inflammatory signaling pathways, excitotoxicity, oxidative stress, neuroprotection, and the blood-brain barrier, and explores the relationships between the gut microbiota and vitamins in epileptic disorders with a focus on summarizing the antiepileptic effects of vitamin D and vitamin E

These medications must be stopped at least 2 months before planned pregnancy and are not suitable during pregnancy or breastfeeding

From May 2025, they started prescribing only FDA-approved medications