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Until recently they have had little support from the two dominant GLP-1 drug makers, Novo Nordisk and Eli Lilly who have not considered addition a high prioroty (Sheridan)

Because retatrutide significantly reduces appetite and slows gastric emptying, individuals participating in clinical trials may consume considerably less food than usual

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Similarly, although medullary thyroid cancer has been linked to GLP-1RAs in rodent studies, there have been very few or no reports of medullary thyroid cancer in clinical trials [4, 9, 67, 68]

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