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Diabetologia, 60, 15771585

A persistent administration of morphine that targets -opioid receptor downregulates the signal, requiring higher dosage of morphine to elicit the original level of response [1518]

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As a representative example of this advanced in vitro approach, in 2021 Peter Ertls group established a synovium-on-chip platform that leverages patient-derived FLS

At the facility, 120 L of water was added to the samples, which were then sonicated for an additional 15 min