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287,293 Paralleling findings in humans, findings from several established animal models of ASD, including offspring with maternal immune activation (MIA) (IL2, IL6 and IL17) 294,295,296 and offspring of VPA-treated rodents (TNF- and IL-6), 297 and the naturally occurring BTBR strain (IL-33, IL-18, IL-1 and CXCL7) 298,299 have also shown alterations in the secretion of cytokines and chemokines

Cells were treated with 1 nM thapsigargin (Tg) for indicated time

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"The anti-inflammatory effects of methylsulfonylmethane on lipopolysaccharide-induced inflammatory responses in murine macrophages"

In comparison, the stable gastric pentadecapeptide BPC 157, an emerging treatment with potential therapeutic applications, appears to be unrestricted by the limitations seen in previous therapies

Some of the peptide may be broken down before it can exert its full effect on systemic tissues outside the gut