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And it certainly is very distressing for a lot of patients of mine

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Recuperato da: Thomsen M, Dencker D, Wrtwein G, Weikop P, Egecioglu E, Jerlhag E, et al

MMA is a genetically heterogeneous disorder, with the majority (~60%) of cases caused by complete ( mut 0 ) or partial ( mut ) deficiency of the enzyme methylmalonyl-CoA mutase (MMUT) and the remainder due to errors in the synthesis or transport of 5-deoxyadenosylcobalamin, a vitamin B 12 derivative and essential cofactor of the reaction (1, 2)

Body-weight fluctuations and outcomes in coronary disease

Doctors may also recommend specific dietary and lifestyle changes to balance the effects of both drugs