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People who consume diets free of animal products as well as those who have pernicious anemia (i.e., malabsorption) are at a greater risk of developing vitamin B12 deficiency

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Safety Advantage: Astaxanthin+ by Innerbody Labs Astaxanthin is generally well-tolerated in healthy adults, with clinical studies showing no serious side effects at doses up to 24mg per day for extended periods.11 Most supplements provide between 4mg and 12mg daily well within the range confirmed safe in human trials and safety reviews

Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS

Those are the doses supported by safety and efficacy data