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-MSH Analog Cyclic Heptapeptide University of Arizona Originator Literature Reported Mechanism (Literature) Non-Selective Melanocortin Receptor Agonist Pan-MCR activation (MC1R, MC3R, MC4R, MC5R) Al-Obeidi and colleagues (1989, PMID 2555512) designed Melanotan II as a non-selective melanocortin receptor agonist with 100-fold enhanced melanotropic potency versus -MSH in the lizard skin bioassay
Effective and early glycaemic control after diagnosis of T2D and control of other CV risk factors can prevent CV events
For example, if phenytoin levels are therapeutic, the administration of a drug competing for protein binding could double the free phenytoin level (if protein binding decreases from 90% to 80%)
Diabetes Care 31 , 18161823, (2008)
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