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GLP-1 Medications: A Different Mechanism for Sustainable Weight Loss GLP-1 receptor agonists such as semaglutide work by mimicking glucagon-like peptide-1, a hormone your body naturally produces in the intestines and brain

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Yamamoto H, Kishi T, Lee CE, Choi BJ, Fang H, Hollenberg AN, Drucker DJ, Elmquist JK: Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites

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