Semaglutide 2.4 mg once a week in adults with overweight or obesity, and type 2 diabetes (STEP 2): a randomised, double-blind, double-dummy, placebo-controlled, phase 3 trial
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In clinical trials, the 12 mg maintenance dose produced 24.2% body weight loss at 48 weeks (Phase 2) and 28.7% at 68 weeks (Phase 3)
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I did experience some fatigue and mild constipation when I moved from 2 mg to 4 mg, but it settled after a few days
54 This trial emphasized that orforglipron might provide an alternative to injectable GLP-1 receptor agonists and oral semaglutide, with the prospect of less burdensome administration to achieve treatment goals in diabetics