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found that GLUD1 is highly expressed in hepatocellular carcinoma, which enhances intracellular mitochondrial respiratory activity and generates large amounts of ROS

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These are, of course, not the only medications that can have rare but extremely severe, even fatal side effects, and it doesnt meant that they arent solid Type 2 Diabetes medications

However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy