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Because oral glutathione supplements have historically demonstrated poor bioavailability and are rapidly broken down by enzymes in the gastrointestinal tract, the body relies heavily on intracellular de novo synthesis to maintain its protective antioxidant pools

Upon encountering proteasessuch as kallikrein or activated components of the complement cascadeITIH4 undergoes proteolytic cleavage, forming complexes with the active enzyme that can effectively neutralize or diminish enzymatic activity

10.4103/1673-5374.255974 261 LeeJ.ParkS

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