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SURPASS-1 (NCT03954834) was a 40-week double-blind trial that randomized 478 adult patients with type 2 diabetes mellitus with inadequate glycemic control with diet and exercise to subcutaneous MOUNJARO 5 mg, MOUNJARO 10 mg, MOUNJARO 15 mg, or placebo once weekly

According to the previous findings, the 150 g/kg dosage of Dula is superior to lower dosages while not significantly deviating from the SLZ groups findings in terms of lowering the high levels of PI3K and AKT

With insurance but no savings card: Out-of-pocket costs often fall between $60 and $150 per month, depending on drug tier placement, deductibles, and coinsurance

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Key Takeaways at a Glance Bottom line: Most GLP-1 fatigue is practical, not mysterious: appetite drops, intake shrinks, fluids/electrolytes slip, and GI side effects disrupt routines

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