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Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis-mediated cell death
Phase 3 trials (LIPO-010 and CTR-1011) involving 806 patients demonstrated 19.6% and 11.7% visceral fat reduction respectively
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In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response ( 3.2 Intestinal mucosal barrier IELs are a heterogeneous population of T cells located among intestinal epithelial cells (IECs), where they contribute to maintaining mucosal barrier integrity (59, 60)
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