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[PMID: 12897445] Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL

Combined antioxidant, anti-inflammaging and mesenchymal stem cell treatment: a possible therapeutic direction in elderly patients with chronic obstructive pulmonary disease

Lastly, to bring things back to mitochondria and energy levels, 4 g/d of ALCAR has been shown to improve cognitive function, reduce mental and physical fatigue, and improve the ability to function in daily life compared to a placebo in elderly adults complaining of excessive fatigue [29]

The foundational chemistry was reported by Al-Obeidi, Castrucci, Hadley, and Hruby in J Med Chem 1989, describing the design rationale based on molecular dynamics modeling [2]

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