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Choose Semaglutide If: You want the medication with the longer real-world safety record and more accumulated clinical data You've had previous GI sensitivity to medications and want to start with the option that may be slightly better tolerated You have a strong cardiovascular history and your provider wants the extensive SUSTAIN cardiovascular outcomes data behind your treatment You've already tried semaglutide and responded well there's no reason to switch what's working Choose Tirzepatide If: You want the medication with the strongest average weight loss outcomes in clinical trials You have significant insulin resistance or type 2 diabetes where the dual GIP/GLP-1 mechanism provides added metabolic benefit You've plateaued on semaglutide and want to try the additional GIP pathway You're comfortable with a newer medication that has a rapidly growing and compelling safety and efficacy record Not Sure Which Is Right for You

The investigators concluded that "ongoing treatment is required to maintain improvements in weight and health." How to Help Patients Afford Weight Loss Medications # Given that the costs of many weight loss medications are high, insurance often does not cover them, and stopping stymies their benefits, how can you best help patients who want to take them

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What you need to know This article was reviewed by Craig Primack, MD, FACP, FAAP, FOMA

Fermentation of fiber by gut bacteria also produces short-chain fatty acids that directly stimulate L-cells