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To evaluate the success of the modifications that were incorporated in dihexa in this regard rats were fitted with carotid cannulas and infused with of 3 H-dihexa and 2 of 14 C inulin, a vascular space marker

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Published data suggests up to 2.6% incidence of B12 deficiency within a year of treatment, and this figure climbs in patients who have used these medications long term or combined them with very low calorie diets (3)