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Microglia are the resident immune cells of the CNS and act as the first line of defense against injury and infection

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The brain consumes a massive amount of oxygen and is highly susceptible to oxidative stress, which manifests clinically as severe brain fog, memory impairment, and neuroinflammation

The impact of neuroinflammation on neurotransmitter systems is further emphasized by the role of specific cytokines [130]

High delta sleep-inducing peptide-like immunoreactivity in plasma in suicidal patients with major depressive disorder

This makes it particularly interesting for patients with neurodegeneration, brain injury , or even post-viral cognitive issues