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Am J Physiol Endocrinol Metab 302(6):E666EE73 Steinert RE, Beglinger C, Langhans W (2016) Intestinal GLP-1 and satiation: from man to rodents and back

SREBP-2 additionally influences low-density lipoprotein cholesterol (LDL-C) uptake by upregulating LDL receptor (LDLR) and proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression

These findings, in line with several recent studies reporting the protective effects of statins in various kidney diseases [42,43,44,45], underscore the critical role of lipid metabolic dysregulation in CaOx-induced renal injury and suggest that pharmacological modulation of lipid metabolism may serve as a complementary strategy to targeting the PRMT1/UBE2m axis

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In addition, local berries such as blueberries, lingonberries and strawberries play an important role in the HND

It is important to note that this concern is entirely theoretical -- no oncological adverse effects have been reported in the limited preclinical studies -- but the biological plausibility is high enough to warrant serious consideration