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Mechanistic studies also suggest that metformin can influence multiple hallmarks of AD pathology, including neuronal loss, A deposition, tau phosphorylation, and chronic neuroinflammation 54

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Experimental applications emphasize system-level observation of energy regulation and glucose handling , using controlled conditions to generate reproducible laboratory data

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[ CrossRef ] [ Google scholar ] [ PubMed ] Severyanova L, Dolgintsev ME