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RAS/MAPK signaling functions in oxidative stress, DNA damage response and cancer progression

Every day, it processes toxins from food, water, and even air

The PI3K/Akt pathway activated by IGF1R is a major anti-apoptotic pathway in neurons, which drives interest in IGF1R agonism as a potential neuroprotective strategy in preclinical research

doi: 10.1002/ajmg.b.10069 592 BirdTD

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On the other hand, IGF-1R has been shown to be crucial for anchorage independent growth, a property being well established to be unique for malignant cells