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Federici MO, McQuillan J, Biricolti G, et al

Front Aging Neurosci 9:365 Dodge JC, Haidet AM, Yang W, Passini MA, Hester M, Clarke J, Roskelley EM, Treleaven CM, Rizo L, Martin H, Kim SH (2008) Delivery of AAV-IGF-1 to the CNS extends survival in ALS mice through modification of aberrant glial cell activity

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This includes depressive disorders (F32-33), anxiety (F40-F48), and various aspects of suicidality

It isnt specifically approved for MC4R deficiency specifically, only for weight management and appetite control in adults and children with POMC- , PCSK1- , or LEPR- deficient obesity or those with genetically confirmed pathogenic variants, likely pathogenic variants, or variants of uncertain significance in POMC , PCSK1 , or LEPR (FDA: 2 years of age and older