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PreciseBreast test (0220U) 1 is a cancer-related protein-based multi-analyte algorithmic test, however, because it is assigned a Proprietary Laboratory Analyses (PLA) code by AMA CPT Editorial Panel, it does not meet the exclusion from the DOS policy under CMS's current interpretation

Differential diagnosis: Cholangiocarcinoma (poorly differentiated)glandular structures with mucus production are present