They slow gastric emptying , prolonging the feeling of fullness after meals, and act on appetite centres in the brain to reduce hunger signals
Some patients take GLP-1s for a shorter time to jumpstart their weight loss, while others may benefit from extending their treatments to help improve health conditions or for continued weight management support
Success depends on many factors, including weight history, metabolic risk, appetite, activity, nutrition, sleep, stress, medical conditions, and medication history
Phase 3 TRIUMPH-4 results (68 weeks): 9mg dose: 26.4% average weight loss (29.1 kg) 12mg dose: 28.7% average weight loss (32.3 kg) Placebo: 2.1% average weight loss The 12mg retatrutide group lost an average of 71.2 pounds
Not everyone responds to GLP-1 medication in the same way
If 8mg Retatrutide controls appetite effectively and produces satisfactory weight loss, pushing to 12mg adds side effect burden for incremental benefit