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Significant weight loss often occurs only after reaching higher maintenance doses

It groups those indirect approaches as low-glycemic and protein-rich diets, herbal supplements, exercise and sleep optimization, and behavioral strategies such as portion control

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Research in animal models demonstrates improved insulin sensitivity, enhanced fat oxidation, and protection against diet-induced obesity

GLP-1Rs are expressed in the heart, but it is unclear if they have a role in cardioprotection, or if they are primarily involved in the regulation of BP and heart rate (103, 104, 224)