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Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats

Going forward this provides a valuable yardstick for evaluating the benefits of GLP-1 drugs which have been used since 2005

Limitations and Candidacy This section exists because it is the most important one for a GLP-1 patient trying to make a well-informed decision

Furthermore, both GLP-1 monotherapy and GLP-1MK-801 treatment resulted in decreased plasma triglyceride levels compared with the vehicle treatment (Fig

Endocrinology 144: 5149-5158, 2003

Exposure-response analysis for evaluation of semaglutide dose levels in type 2 diabetes