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Crucially, IBD management has shifted from merely controlling symptoms to halting disease progression through intestinal reparative therapy. In this context, true repair is strictly defined by objective endpoints such as endoscopic healing and histologic healing, rather than subjective clinical remission

Nasal mucosal epithelial cells demonstrated reduced apoptotic marker expression including cleaved-CASP-3, cyt-c, NLRP3, ASC, IL-1, IL-18, CASP-1, and cleaved CASP-1, and increased Bcl-2, confirmed by TUNEL-positive apoptotic cell reduction, suggesting an inhibition of anti-apoptotic and anti-inflammatory effects on nasal tissue [219]

Soltan-Sharifi et al., 2007): Soltan-Sharifi also reported that supplemental NAC resulted in the prevention of this aggravating condition (Soltan-Sharifi et al., 2007)

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