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Along with AMPK protein reduction, YBX1 expression was also decreased in shGDH1 cells and rescued by exogenous -KG (Fig

Compare with those in BLM group, the top genes exhibiting significantly decreased expression were mostly involved in ECMreceptor interaction, cytokinecytokine receptor interaction, phagosome, chemokine signalling pathway, focal adhesion and PI3KAkt signalling pathway

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Specifically, PD-1/PD-L1 binding induces phosphorylation of the immunoreceptor tyrosine inhibitory motif (ITIM) and immunoreceptor tyrosine switch motif (ITSM) regions of PD-1, which attract and activate tyrosine phosphatases Src homology phosphatase 1 (SHP-1) and Src homology phosphatase 2 (SHP-2)

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