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sterically induced, spontaneous dealkylation of secondary alkylcobalamins due to axial base coordination and conformational changes of the corrin ligand

At its IC50 concentration, vincristine induced significant downregulation of Ribonucleotide Reductase M2 (RRM2), involved in DNA damage repair and cell cycle regulation ( Supplementary Table S1 )

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Manufacturer Suggested Use: As a dietary supplement, take 1 teaspoon (5ml) once daily