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10.3389/fmed.2022.955560 23 DominguesR
Possibly, but only with careful medical evaluation and ongoing monitoring
Also, hepatocytes begin to dedifferentiate and change their gene expression profile in culture, such that mitochondrial structure and function specific to MMA might not be recapitulated in such in vitro studies, limiting their utility
A duodeno--ileal loop
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Importantly, AKT inhibitors are already in clinical development for other metabolic and oncologic disorders, potentially accelerating drug repurpose efforts
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