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Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1) governs this process by activating multiple transcription factors, including nuclear respiratory factors 1 and 2 (NRF-1 and NRF-2) and mitochondrial transcription factor A (TFAM) (46)

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Zhou, X., Cao, Q., Orfila, C., Zhao, J., & Zhang, L

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Heterochromatin: an epigenetic point of view in aging