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Cold temperature numbs nerve endings and reduces inflammation, which minimizes itching

You need to keep taking medications to manage other chronic conditions, like an autoimmune disease or high blood pressure

This approach ensures that GLP-1 therapy is tailored to those most likely to benefit from improved metabolic health, weight reduction, and reduced risk of other health conditions such as cardiovascular issues and blood sugar imbalances

ClinicalTrials.gov A Study of Retatrutide (LY3437943) Once Weekly in Participants With Obesity and Knee Osteoarthritis (TRIUMPH-4)

Supply constraints are likely in the first weeks post-launch, similar to early Wegovy and Zepbound shortages

FDA.gov Sanyal AJ, Cusi K, Hartman ML, et al