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doi: 10.3748/wjg.v16.i19.2448

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Clinical trials vs real-world results What the clinical trials show The landmark SURMOUNT-5 trial published in 2025 compared these medications directly at standard maximum doses: 1 Mounjaro (tirzepatide 15 mg) produced 20.2% average weight loss Wegovy (semaglutide 2.4 mg) produced 13.7% average weight loss The 6.5 percentage point difference was statistically significant This trial used the maximum approved doses at the time (Mounjaro 15 mg, Wegovy 2.4 mg) and lasted 72 weeks

Another possible mechanism is a compensatory increase in TSH and FT3 secretion to overcome decreased tissue responsiveness to circulating THs, due to reduced expression of both TSH and THs in adipocytes of individuals with obesity [128]

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Flushing or warmth in the face : A temporary reaction some patients notice