doi: 10.1016/J.IJID.2022.03.006 23 MendelsonMNelJBlumbergLMadhiSADrydenMStevensWet al
11 Reduced nitric oxide and increased reactive oxygen species independently both lead to increased oxygen consumption
The LEADER trial (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) followed over 9,000 patients for a median of 3.8 years and reported similar cancer rates between liraglutide and placebo groups
Drawbacks to this method include the small sampling size of bulk materials which reduces sensitivity, and detection of microorganism growth based on a visual observation
CVOTs In response to FDA guidelines requiring the assessment of anti-diabetic therapeutics in relation to cardiovascular risk, several CVOTs have been performed
Woods A, Dickerson K, Heath R, Hong SP, Momcilovic M, Johnstone SR, et al