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HbA1c staying above target despite metformin Overweight or obesity, especially the abdominal fat pattern common in Indians Existing cardiovascular disease or high cardiac risk a topic we cover in depth in Part 8: GLP-1, Heart and Kidney Benefits Chronic kidney disease, where GLP-1 drugs have shown protective signals [7] A need to avoid hypoglycemia or further weight gain, which older drugs like sulfonylureas often cause DPP-4 inhibitors such as teneligliptin, sitagliptin, vildagliptin, and linagliptin are widely prescribed in India and lower blood glucose with a low risk of hypoglycemia

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Amid concerns of losing its first-mover advantage to competitors like Eli Lilly, the company also saw a change in leadership with the ousting of its CEO in May 2025

Saulsberry WJ, Coleman CI, Mearns ES, Zaccaro E, Doleh Y, Sobieraj DM

& Berthold, H

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