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A 2025 systematic review identified 36 studies from 1993 to 2024, including 35 preclinical studies and only 1 clinical study

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Chiorini, D

Albuterol is longer acting than isoproterenol in most patients by any route of administration because it is not a substrate for the cellular uptake processes for catecholamines or for COMT Less than 20% of a single albuterol dose is absorbed systemically following nebulizer administration Albuterol does not readily cross the blood brain barrier Bronchodilation is maximal in ~15 minutes, and persists for 3-4 hours

Devaraj S, Siegel D, Jialal I

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