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PNP, an enzyme that is part of the nucleotide metabolism via degradation of deoxyguanosine, is involved in NR metabolism in mammalian cells by metabolizing NR to NAM

Any disruption along this pathway can lead to deficiency regardless of dietary intake, which is why some patients need supplementation even when they eat B12-rich foods

Some common immediate side effects may include swelling, bruising, pain, burning, itchy skin, and discomfort

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A wide diversity of bacteria from the human gut produces and degrades biogenic amines

[7] Although the FDAs newer labeling system has moved away from letter categories, the consensus remains that MB may cause fetal harm and thus should be avoided in pregnant women whenever possible